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Glembatumumab vedotin
CAS No. 1182215-65-1
Glembatumumab vedotin( —— )
Catalog No. M36588 CAS No. 1182215-65-1
Glembatumumab vedotin (CDX-011) is an antibody-drug conjugate with potent anticancer effects, utilized in the study of triple negative breast cancer (TNBC).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 1091 | Get Quote |
|
| 5MG | 1444 | Get Quote |
|
| 10MG | 1881 | Get Quote |
|
| 25MG | 2732 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameGlembatumumab vedotin
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NoteResearch use only, not for human use.
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Brief DescriptionGlembatumumab vedotin (CDX-011) is an antibody-drug conjugate with potent anticancer effects, utilized in the study of triple negative breast cancer (TNBC).
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DescriptionGlembatumumab vedotin (CDX-011) is an ADC (antibody-drug conjugates (ADCs)) comprising a fully human IgG2 monoclonal antibody (CR011) directed against glycoprotein NMB (GPNMB) and conjugated to the potent tubulinbinding cytotoxic agent MMAE via a protease-sensitive vc linker. Glembatumumab vedotin has potent anticancer effects.
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In VitroCell Viability Assay Cell Line:Osteosarcoma cell lines Concentration:1 μg/mL to 125 μg/mL Incubation Time:96 hours Result:Demonstrated osteosarcoma cytotoxic activity.
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In VivoAnimal Model:Athymic mice (6-week-old) injected with human SK-MEL-2 and SK-MEL-5 melanoma cells Dosage:1.25 mg/kg, 2.5 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg, 40 mg/kg, 60 mg/kg, 80 mg/kg Administration:i.v.; every 4 days; for 16 days Result:Showed inhibition of tumor growth.
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Synonyms——
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PathwayOthers
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TargetOther Targets
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RecptorMicrotubule Associated | Antibody-Drug Conjugates (ADCs)
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Research Area——
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Indication——
Chemical Information
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CAS Number1182215-65-1
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Formula WeightApproximatel 149.16 kDa
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Molecular Formula——
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Christopher H Keir, et al. The use of an antibody drug conjugate, glembatumumab vedotin (CDX-011), for the treatment of breast cancer. Expert Opin Biol Ther. 2012 Feb;12(2):259-63. ?
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